Would it be possible to opperate an ion engine with other gasses apart from the noble gases currently in use? Lets say for example hydrogen? and if so,what benefits dissadvantages do different gasses represent?

(may be broke/outdated!)
Would it be possible to opperate an ion engine with other gasses apart from the noble gases currently in use? Lets say for example hydrogen? and if so,what benefits dissadvantages do different gasses represent?